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Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 17-178
Full Name: Lea Rath-Wolfson
Position: Senior Lecturer
Age: ON
Sex: Female
Address: 31 Habustan st. Herzelia
Country: ISRAEL
Tel: 9372389
Tel prefix: 972-3
Fax: 972-3-9372349
E-mail address: leavo@clalit.org.il
Other E-mails: leawolfson@gmail.com
Title of the Paper: over expression of metalloproteinase-1 in human colonic carcinomas and its prognostic value
Authors as they appear in the Paper: Lea Rath-Wolfson, Edward Ram, Roy Bubis, Asaf Shvero, Rumelia Koren
Email addresses of all the authors: leavo@clalit.org.il,edwardrm@netvision.net.il,roybubis@gmail.com,asafshviro@hotmail.com,rumeliak@clalit.org.il
Number of paper pages: 8
Abstract: Colorectal cancer (CRC) represents a serious health problem and the search for additional prognostic factors is on going. In this study we wanted to examine the expression of Matrix Metalloproteinase 1 (MMP-1) by immunohistochemical method in colorectal cancer and its relation to clinicopathological features. Sixty eight consecutive patients with CRC were treated at our center were chosen to participate. Representative samples from each tumor were stained immunohistochemically for MMP-1. Its intensity expression was graded as positive or negative. Normal colon tissue samples were used for control. In general the survival curve of the positive MMP-1 patients was worse than that of the negative ones, but the difference was not statistically significant (p = 0.125). However, survival time was significantly shorter for patients with positive MMP-1 who did not receive chemotherapy treatment than the negative ones, (p = 0.019). When considering the gender of the patient!
, survival time showed a statistically significant difference between male patients with positive and negative MMP-1 indication (p = 0.04), but the difference for female patients was not statistically significant.
Keywords: MMP-1,Immuohistochemistry,Colorectal carcinoma.
EXTENSION of the file: .doc
Special (Invited) Session: Over expression of Metalloproteinase-1 in human colonic carcinomas and its prognostic value
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