The following information was submitted:
Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 19-152
Full Name: Marcio Moreira
Position: Doctor (Researcher)
Age: ON
Sex: Male
Address: Av. Tiradentes, 1084 - Zona 01 - 87013-260 - Maringá - Paraná
Country: BRAZIL
Tel: 44-3262-2241
Tel prefix: 55
Fax: 44-3262-2241
E-mail address: marciomoreiradr@brturbo.com.br
Other E-mails: plasticlinic@brturbo.com.br
Title of the Paper: The papain local depot impairs the capsule fibrous healing around textured silicone implants in rats.
Authors as they appear in the Paper: Marcio Moreira, Djalma José Fagundes
Email addresses of all the authors: marciomoreiradr@brturbo.com.br, djfagundes.dcir@epm.br
Number of paper pages: 11
Abstract: Abstract - Objetive: To study the tissue repair around the textured mammary implants under the action of papain (PA). Methods: Thirty-six Wistar rats were evaluated and randomly distributed into two groups (n = 18): papain (PA) and control (CT). Each group was equally distributed into 3 subgroups (n = 6) and observed on seventh, thirtieth-fifth and ninth pos-operative days. Each animal received a textured implant in the left dorso-axillary region (sham - SH), on were instilled 0.5 mL saline solution 0.9%, and another textured implant on the right dorso-axillary region (papain - PA), on were instilled 0.5 mL of water-soluble solution of papain. The control group (CT) received only textured implant in the left dorso-axillary region with prior instillation of 0.5 mL of saline solution 0.9%. The histological analysis of the 3 subgroups was carried out using picrosirius-red stain and an image analyzing system using the Image Pro Plus™ program to evaluate the thickness a!
nd maturation and deposition of collagen fibers. Immunohistochemical evaluation was performed, using micrometric reticules of Weiss (Olympus Labstore™), for myofibroblasts counting only in the 90th day subgroup. Results: At 35th and 90th days, the papain group (PA) presented reduction on the fibrous capsule thickness around the implant, in the number of collagen fibers and myofibroblasts, comparing to the control group (CT). Conclusion: The papain drug decreased the fibrous capsule formation around the textured silicon implants in rats.
Keywords: Mammary implant, Capsular contracture, Inflammation, Capsular thickness
EXTENSION of the file: .rtf
Special (Invited) Session: The papain pocket delivery impairs the capsule fibrous healing around textured silicone implants in rats.
Organizer of the Session: 618-371
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