The following information was submitted:
Transactions: INTERNATIONAL JOURNAL of MATHEMATICAL MODELS AND METHODS IN APPLIED SCIENCES
Transactions ID Number: 17-231
Full Name: Chontita Rattanakul
Position: Assistant Professor
Age: ON
Sex: Female
Address: Department of Mathematics, Faculty of Science, Mahidol University,Bangkok, 10400
Country: THAILAND
Tel: 6687984766
Tel prefix:
Fax: 6622015343
E-mail address: sccrt@mahidol.ac.th
Other E-mails: g4136815@yahoo.com
Title of the Paper: effect of calcitonin on bone formation and resorption:mathematical modeling approach
Authors as they appear in the Paper: Chontita Rattanakul,Sahattaya Rattanamongkonkul
Email addresses of all the authors: sccrt@mahidol.ac.th,sahattay@buu.ac.th
Number of paper pages: 9
Abstract: We study the effect of calcitonin on bone formation and resorption mathematically by developing a system of nonlinear differential equations to describe the process. The model accounts for the concentration of calcitonin above the basal level, the number of active osteoclastic cells and the number of the active osteoblastic cells. We then applied the singular perturbation to our model in order to obtain the conditions on the system parameters for which the various kinds of dynamic behavior can be occurred. Computer simulations are also carried out to support our theoretical predictions. The results show that a periodic behavior can be expected corresponding to the pulsatile secretion pattern of calcitonin observed clinically in normal individuals.
Keywords: Bone formation,Bone resorption,Calcitonin,Mathematical model,Singular perturbation
EXTENSION of the file: .pdf
Special (Invited) Session: a mathematical model of bone formation and resorption:effect of calcitonin
Organizer of the Session: 303-181
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