The following information was submitted:
Transactions: WSEAS TRANSACTIONS ON COMPUTERS
Transactions ID Number: 29-107
Full Name: Mahanand B s
Position: Lecturer
Age: ON
Sex: Male
Address: Department of Information Science and Engineering, Sri Jayachamarajendra College of Engineering, Manasagangotri, Mysore 570 006
Country: INDIA
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E-mail address: bsmahanand@gmail.com
Other E-mails: bsmahanand@sjce.ac.in
Title of the Paper: analysis of Alzheimer’s disease progression in structural magnetic resonance images
Authors as they appear in the Paper: Mahanand B s, Aswatha kumar M
Email addresses of all the authors: bsmahanand@gmail.com,maswatha@yahoo.com
Number of paper pages: 10
Abstract: Structural magnetic resonance imaging (MRI) of the brain is an increasingly useful tool in the study of neurodegenerative diseases. MRI is currently the fastest developing medical imaging modality which is applied to an increasingly number of different medical diagnostic situations. Serial acquisition structural images of a subject’s brain are acquired over time offers opportunities to monitor the progression of tissue volume changes in fine detail at all anatomical locations. As a result, the analysis of structural MRI data has been an active area of image analysis research for many years especially in early diagnosis, tracking of disease progression, which makes it possible to investigate how, for instance, a patient responds to treatment. The aim of the paper is to investigate and analyze brain tissue changes in Alzheimer’s disease using non-rigid medical image registration and statistical analysis techniques. In our proposed approach, first the source and t!
he target images are affinely registered to correct global differences between the images and then non-rigid registration based on free-form deformation using B-spline approximation is performed on the images. The resulting displacement values from the non-rigid registration are further investigated for deformation in the entire brain to detect typical deformation patterns. Finally, statistical method namely t-test is performed for analysis of the results. The initial results indicate that the tissue volume change in the brain occurs predominantly in the hippocampus of the brain.
Keywords: Magnetic resonance imaging, Image registration,Free-form deformation,Alzheimer’s disease,Statistical analysis,T-test
EXTENSION of the file: .pdf
Special (Invited) Session: Deformation field analysis of magnetic resonance images in Alzheimer’s disease
Organizer of the Session: 609-358
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