Thursday 22 January 2009

Wseas Transactions

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Transactions: WSEAS TRANSACTIONS ON COMPUTERS
Transactions ID Number: 32-163
Full Name: Tarek Gharib
Position: Associate Professor
Age: ON
Sex: Male
Address: Faculty of Computer and Information Sciences, Ain Shams University, Cairo 11566, Egypt
Country: EGYPT
Tel: 002-010-6066683
Tel prefix:
Fax: 00202-33458610 ext. 216
E-mail address: tgharib@eun.eg
Other E-mails: mtarek62@yahoo.com
Title of the Paper: A Hybrid Approach for Indexing and Searching Protein Structure
Authors as they appear in the Paper: Tarek F. Gharib
Email addresses of all the authors: tgharib@eun.eg
Number of paper pages: 10
Abstract: Searching for structural similarities of proteins has a central role in bioinformatics field. Most tasks of bioinformatics depends on investigating the homologous protein's sequence or structure these tasks vary from predicting the protein structure to determine sites in protein structure where drug can be attached. Protein structure comparison problem is extremely important in many tasks. It can be used for determining function of protein, for clustering a given set of proteins by their structure, for assessment in protein fold prediction. Protein Structure Indexing Using Suffix Array and Wavelet (PSISAW) is a hybrid approach that provides the ability to retrieve similarities of proteins based on their structures. Indexing the protein structure is one approach of searching for protein similarities. We use the suffix arrays to index protein structure and use wavelet to compress the indexed database. Compressing the indexed database is supposed to make the searchin!
g time faster and memory usage lower but it affects the accuracy with accepted rate of error.The experimental results, which are based on the structural classification of proteins (SCOP) dataset, show that our method outperforms existing similar methods in memory utilization and searching speed. Our results show an enhancement in the memory usage with factor 50%.
Keywords: protein structures, indexing, suffix array, wavelet
EXTENSION of the file: .doc
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