The following information was submitted:
Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 19-286
Full Name: Milena Adina Man
Position: Senior Lecturer
Age: ON
Sex: Female
Address: Caraiman 3 street
Country: ROMANIA
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E-mail address: manmilenaadina@yahoo.com
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Title of the Paper: Survival patients with pulmonary metastases in testicular cancer
Authors as they appear in the Paper: Man Milena Adina, Antigona Trofor, Dana Alexandrescu, Ovidiu Balanescu, Ioana Neagoe, Pop Monica, Ruxandra Rajnoveanu
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Number of paper pages: 11
Abstract: Testicular cancer is a rare disease reaching only 1% of all cancer types characteristic to men with ages between 15 and 34 years and has shown an increasing worldwide incidence over the past 30 years. In contrast, the mortality rate has decreased. Hematogen metastases are responsible for the apparition of pulmonary nodules. Determining the pulmonary relapse model, studying prognosis factors for defining risk groups and applying different therapeutic strategies with the evaluation of survival represent the study's main objectives. We conducted a survey from January 2000 to December 2005 on 17 patients admitted in Cluj-Napoca Oncology Institute. We introduced in the study patients diagnosed with testicular carcinoma and pulmonary metastases, we analyzed risk factor and evolution of the diseases with survival function calculated since cancer diagnosis, and the other calculated since pulmonary metastases. We evaluated the risk factors correlated with survival: the ave!
rage age ,place of origin, histology tumor markers for our batch: Beta HCG, AFP (alpha-fetoprotein), LDH ,types of pulmonary metastases, the presence of other metastases, the number of metastatic locations, the time span between the apparition of symptoms and diagnosis, the free interval the diagnosis of the primary tumor and metastasis, and value of tumor markers at the time of diagnosis. Based on these prognosis factors, the patients were divided into a good prognosis category (good) and unfavorable (poor) . Because the risk factors usually available are not sufficient to identify the subgroups of patients with an unfavorable prognosis, we tried to evaluate new genetic markers which could prove their prognosis value. We also sought to evaluate the involvement of the hTERT gene in testicular pathology. Patients with metastases will have a different prognosis depending on the relapse model and will require individual strategies selected based on the risk factors by combi!
ning available therapeutic modalities. Early diagnosis and treatment o
f metastasis may lead to an improvement in the survival rate of cancer patients
Keywords: prognostic factor, survival, pulmonary metastases hTERT Gene, testicular carcinomas, risk factor
EXTENSION of the file: .pdf
Special (Invited) Session: The Prognosis Value of the hTERT Gene in the Evaluation of Pulmonary Metastasized Testicular Carcinomas on a Reduced Number of Cases
Organizer of the Session: 640-370
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