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Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 19-582
Full Name: Corina Grigore
Position: Researcher
Age: ON
Sex: Female
Address: Internal Medicine Department, "Coltea" Clinical Hospital, I.C.Bratianu Blvd, no.1-3, Bucharest
Country: ROMANIA
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E-mail address: corina.grigore@yahoo.com
Other E-mails: inaf78@gmail.com
Title of the Paper: Oxidative Stress, Uric Acid, Vascular Inflammation in Non-Smoking Metabolic Syndrome Patients
Authors as they appear in the Paper: Corina Grigore, Irina Stoian, Ovidiu Grigore, Luminita Dawkins, Dan Isacoff, Ion Bruckner
Email addresses of all the authors:
Number of paper pages: 9
Abstract: Abstract— Substantial evidence states that serum uric acid is an important, independent risk factor for cardiovascular and renal disease especially in patients with hypertension, heart failure, or diabetes, relative to the oxidative stress that alters the plasma lipoprotein profile, the coagulative parameters, the endothelium and the cell membranes, but this is not supported by large scale clinical studies. There is increasing evidence that inflammation and endothelial dysfunction are the most important pathogenic pathways explaining the propensity to atherosclerosis and its complications in metabolic syndrome. Most adipocytokines and proinflammatory biomarkers (adiponectin, cell adhesion molecules, TNF-á, IL, CRP) are elevated in the serum and vessel walls of patients with metabolic syndrome, being positive predictors for cardiovascular events. Aims: To investigate uric acid, oxidative stress, hs C-reactive protein and classical cardiovascular risk factors, in a !
never treated, non-smoking hypertensive adult patients group (age: 56,9±6,62, sex: m/f=14/22, waist: 93,2±20,3 Kg, ABP: 154.5±14/91.5±8.26 mmHg) with/without MetS vs age-, sex- matched control group. Methods: The concentration of serum and erythrocyte superoxiddismutase (SOD), catalase (CAT) and malonaldialdehyde (MDA) were analysed by spectrofotometry. All the other risk factors (uric acid, fasting glucose, lipid profile) were assessed by validated standard procedures. High sensitive C-reactive protein (hs CRP) has been performed by a sandwich ELISA method. Results: Plasma levels of oxidative stress parameters determined and hsCRP are significantly higher than the control group (p<0.0001). Oxidative stress markers in non-smoking hypertensive group are strongly correlated (r>0.7) with ABP values, the number of criteria for MetS, waist, BMI and hsCRP, they have an average correlation with age, weight, SCORE algorithm and are not correlated with fasting plasma glucose!
, triglyceride, HDL-C. The coefficient of determination is significant
ly increased between the number of criteria for the MetS and oxidative stress parameters. Uric acid levels are correleted on average with weight, waist, BMI, average BP, diastolic BP and have a weak correlation with hs-PCR and oxidative stress parameters. Level of hsCRP activity is strongly correlated with waist, the number of criteria for MetS, oxidative stress markers, SCORE algorithm and has an average correlation with BMI, TG, HDL-C. Conclusions: Increase oxidative stress activity and CRP levels are associated with MetS. When applying multiple linear regression, adjusted for sex, age, classical cardiovascular risk factors, arterial blood pressure becomes a powerful and independent determinant factor of oxidative stress parameters; weight and waist are a powerful and independent determinant factors of hs-CRP values.
Keywords: Keywords—cardiovascular risk factors, high sensitive C-reactive protein, metabolic syndrome, oxidative stress, uric acid
EXTENSION of the file: .pdf
Special (Invited) Session: Oxidative Stress and Vascular Inflammation in Post-menopausal Woman with Metabolic Syndrome
Organizer of the Session: 103-120
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