The following information was submitted:
Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 19-578
Full Name: Alessandra Pica
Position: Associate Professor
Age: ON
Sex: Female
Address: via Mezzocannone 8, 80134 Napoli
Country: ITALY
Tel: 00390812535054
Tel prefix: 0039
Fax: 00390812535035
E-mail address: alessandra.pica@unina.it
Other E-mails: alepica@unina.it
Title of the Paper: Anti-Cancer, anti-Necrotic and Imaging Tumor Marker role of a novel form of Manganese Superoxide Dismutase and its leader peptide
Authors as they appear in the Paper: Alessandra Pica,Annalisa Di Santi,Filomena Basile,Francesca Iacobellis,Antonella Borrelli,Antonietta Schiattarella,Roberto Mancini,Aldo Mancini
Email addresses of all the authors: alessandra.pica@unina.it,annalisa.disanti@unina.it,filomena.basile@unina.it,francyiac@libero.it,antonella_borrelli@tiscali.it, ski.anto@libero.it,robertomancini1983@gmail.com,aldo_mancini@tiscali.it
Number of paper pages: 8
Abstract: The manganese superoxide dismutase (MnSOD) isolated from a human liposarcoma cell line (LSA) was able to kill cancer cells expressing oestrogen receptors, while it did not have cytotoxic effects on normal cells. The oncotoxic activity of the recombinant MnSOD (rMnSOD) was due, likely, to an increase in the level of oxidants in the tumor cells, which have low levels of catalase and, consequently, reach the threshold of toxicity before normal cells. The effectiveness of the rMnSOD in repairing the damage caused by radical excess was further shown by its topical application on necrotic skin. Together with its oncotoxic activity, the rMnSOD exerts a radioprotective effect on normal cells irradiated with X rays. The rMnSOD is characterized by the presence of a leader peptide, which allows the protein to enter cells: this unique property can be used in the radiodiagnosis of cancer or chemotherapy, conjugating radioactive substances or chemotherapic drugs to the leader pe!
ptide of the MnSOD. Compared to traditional chemotherapic agents, the drugs conjugated with the leader peptide of MnSOD can selectively reach and enter only the cancer cells, thus reducing the side effects of the traditional treatments.
Keywords: Anticancer agent, rMnSOD, tumor cells, tumor marker, LSA cells
EXTENSION of the file: .pdf
Special (Invited) Session: A novel form of Manganese Superoxide Dismutase: its Role as anti-Cancer, anti-Necrotic and Tumor Marker for Imaging Analysis
Organizer of the Session: 103-139
How Did you learn about congress: Prof. Chester Glomski: cglomski@buffalo.edu
IP ADDRESS: 62.98.94.102
