The following information was submitted:
Transactions: WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE
Transactions ID Number: 89-197
Full Name: Shunsuke Meshitsuka
Position: Associate Professor
Age: ON
Sex: Male
Address: 86 Nishimachi Yonago Tottori 683-8503
Country: JAPAN
Tel: +81-859-38-6422
Tel prefix:
Fax: +81-859-38-7058
E-mail address: mesh@med.tottori-u.ac.jp
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Title of the Paper: Solution Structure of Homeobox Transcription Factor Hex C-terminal Domain of Negatively Charged Activating Function
Authors as they appear in the Paper: Shunsuke Meshitsuka, Yuki Horie, Kazuya Takahashi, Ojeiru F. Ezomo, Mohammed S. Mustak, Takahisa Ikegami, Tamio Noguchi
Email addresses of all the authors: mesh@med.tottori-u.ac.jp, rapid_shot@hotmail.co.jp,asutoranagan111@yahoo.co.jp, ojezomo@grape.med.tottori-u.ac.jp, mustak@med.tottori-u.ac.jp
Number of paper pages: 10
Abstract: Transcription factor Hex (haematopoietically expressed homeobox) is a homeobox protein that regulates differentiation and development of liver and monocyte. Hex consists of three functional domains, N-terminal proline rich domain, homeodomain and acidic C terminal domain. Other than DNA binding, the function of Hex is to repress and activate transcription of target genes using multiple mechanism. However, the structure and function of Hex-C terminal domain is not yet elucidated. Hence, the present structural studies were carried out by NMR spectroscopy in order to understand the function of the Hex-C domain. We deteremined the NMR assignment of backbone and side chains, and obtained 3D structure of Hex-C domain in the presence of GST tag. This is the first paper to present the structure of a protein with GST tag by NMR.
Keywords: transcription factor, NMR, Hex, GST, protein tag, domain structure
EXTENSION of the file: .pdf
Special (Invited) Session: Solution Structure of Homeobox Transcription Factor Hex C-terminal Domain of Negatively Charged Activating Function
Organizer of the Session: 640-594
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