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Transactions: WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE
Transactions ID Number: 42-304
Full Name: Ka-Lok Ng
Position: Professor
Age: ON
Sex: Male
Address: 500 Lioufeng Road, Wufeng Shiang, Taichung, Taiwan 41354
Country: TAIWAN
Tel: 423323456 ext.1856
Tel prefix: 886
Fax: 886 4 23321019
E-mail address: ppiddi@gmail.com
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Title of the Paper: Vertebrate microRNA genes and CpG-islands
Authors as they appear in the Paper: Ka-Lok Ng, Chien-Hung Huang , Ming-Cheng Tsai
Email addresses of all the authors: ppiddi@gmail.com,chhuang@nfu.edu.tw,zxrwind@yahoo.com.tw
Number of paper pages: 10
Abstract: A portion of five vertebrate species microRNA (miRNA) genes are found to associate with CpG-islands. It is calculated that 74 of 462 (16.0%), 37 of 373 (9.9%), 25 of 234 (10.7%), 25 of 149 (16.8%) and 11 of 177 (6.2%) of the miRNA genes are located within 1000 bp of a CpG-island for human, mouse, rat, chicken and frog respectively. A statistical test is proposed to quantify the probability distribution of the relative distance between a miRNA gene and a CpG-island, the results suggested that there could be some spatial association between them. In the human and mouse samples the Fisher¡¦s exact test indicated that some of the promoter-related miRNA genes are CpG-island-associated. These findings suggest that a potential role of these miRNAs related to CpG-island methylation, which deserve further investigation. A web-based interface has been implemented to facilitate data display, in which the vertebrate CpG-associated miRNA genes results are publicly available.
Keywords: MicroRNA; Promoter regions; CpG-islands; Methylation; Gene regulation
EXTENSION of the file: .doc
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