The following information was submitted:
Transactions: WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE
Transactions ID Number: 42-308
Full Name: Kalok Ng
Position: Professor
Age: ON
Sex: Male
Address: 500, Lioufeng road, Wufeng Shiang, Taichung
Country: TAIWAN
Tel: 4-23323456
Tel prefix: 886
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E-mail address: ppiddi@gmail.com
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Title of the Paper: Vertebrate microRNA genes and CpG-islands
Authors as they appear in the Paper: Ka-lok Ng, Chien-hung Huang, Ming-cheng Tsai
Email addresses of all the authors: ppiddi@gmail.com, chhuang@nfu.edu.tw, tsaimc0527@gmail.com
Number of paper pages: 10
Abstract: A portion of five vertebrate species microRNA (miRNA) genes are found to associate with CpG-islands. It is calculated that 74 of 462 (16.0%), 37 of 373 (9.9%), 25 of 234 (10.7%), 25 of 149 (16.8%) and 11 of 177 (6.2%) of the miRNA genes are located within 1000 bp of a CpG-island for human, mouse, rat, chicken and frog respectively. A statistical test is proposed to quantify the probability distribution of the relative distance between a miRNA gene and a CpG-island, the results suggested that there could be some spatial association between them. In the human and mouse samples the Fisher¡¦s exact test indicated that some of the promoter-related miRNA genes are CpG-island-associated. These findings suggest that a potential role of these miRNAs related to CpG-island methylation, which deserve further investigation. A web-based interface has been implemented to facilitate data display, in which the vertebrate CpG-associated miRNA genes results are publicly available.
Keywords: microRNA; promoter regions; CpG-islands; methylation; gene regulation
EXTENSION of the file: .pdf
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