The following information was submitted:
Transactions: WSEAS TRANSACTIONS ON INFORMATION SCIENCE AND APPLICATIONS
Transactions ID Number: 52-418
Full Name: Fang Rong Hsu
Position: Professor
Age: ON
Sex: Male
Address: No. 100, Wenhwa Rd., Seatwen, Taichung
Country: TAIWAN
Tel: +886-4-24517250 ext.3755
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E-mail address: frhsu@fcu.edu.tw
Other E-mails: jomessha@gmail.com
Title of the Paper: Discovering the Relationship between Single Nucleotide Polymorphisms and Alternative Splicing Events
Authors as they appear in the Paper: Fang Rong Hsu, Wei Chung Shia, Wen Jung Lo, Hsian Chun Lin, Hwan-You Chang
Email addresses of all the authors: {frhsu, p9432656, m9510587}@fcu.edu.tw, 91242009@msa.asia.edu.tw, hychang@life.nthu.edu.tw
Number of paper pages: 10
Abstract: Recent genome-wide analyses show that 40-70% of human genes have alternative splicing forms, meaning that alternative splicing has played a significant role in the complicated functions of the human genome. Therefore the study of alternative splicing has long been a valuable subfield of molecular biology, since the results of such study often serve as useful resources that can take studies of molecular biology to a more advanced level. In our study, we combined multiple data sources including dbSNP, human EST and an alternative splicing database to seek out the relationship between SNP and alternative splicing, and propose an automatic method for large-scale analysis of SNP-alternative splicing pairs. We discovered the relationship between one SNP and one alternative splicing event, and revealed 2,645 novel significant SNPs (P < 0.05) and 1,290 highly significant SNPs (P < 0.001) are correlated to the specific alternative splicing events.
Keywords: Alternative Splicing, SNP, EST, Spliced Associated SNP, Bioinformatics, Genomics
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