The following information was submitted:
Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 20-638
Full Name: Sat Sharma
Position: Professor
Age: ON
Sex: Male
Address: 755 Wellington Crescent
Country: CANADA
Tel: 204 885 7887
Tel prefix: 1
Fax:
E-mail address: ssharma@mts.net
Other E-mails: ssharma@sbgh.mb.ca
Title of the Paper: Physiological Mechanisms of Exercise-Induced Hypoxemia in Athletes
Authors as they appear in the Paper: Peter Lu, Gerard Coneys, Cris LaBossiere, Sat Sharma
Email addresses of all the authors: ssharma@mts.net, umlup@cc.umanitoba.ca, jgdconeys@gmail.com,
Number of paper pages: 10
Abstract: Exercise-induced arterial hypoxemia (EIAH), defined as a significant decrease in oxygen saturation (<95%) during maximal and sub-maximal exercise, is a phenomenon observed in moderately and highly trained athletes. The consequences of EIAH on exercise performance relate to its negative influence on maximal O2 uptake (VO2 max) and impairment of oxygen delivery. The causes of EIAH are yet to be completely elucidated. Proposed mechanisms include ventilation/perfusion inequality, relative alveolar hypoventilation, right-to-left shunt, and diffusion limitation. We hypothesized that development of interstitial pulmonary edema during maximal exercise triggers the physiological mechanisms leading to EIAH. Eleven subjects, who had previously developed EIAH during a similar testing protocol, performed an incremental cycling or running protocol to exhaustion, and pre- and post-exercise lungs scanned using computed tomography. Scans were analyzed both qualitatively and quantit!
atively for the development of pulmonary edema. We employed two different procedures for lung density assessment, specifically, lung sampling technique (Method A) and whole lung measurements (Method B). The lung density measurements were as follows: 0.088±0.008 g/cm3 pre-exercise, 0.090±0.008 g/cm3 post-exercise (p=0.27) with Method A, and 0.190±0.018 g/cm3 pre-exercise, 0.178±0.010 g/cm3 post-exercise (p=0.94) with Method B. These results do not support the presence of interstitial pulmonary edema in individuals known to develop EIAH. Development of interstitial pulmonary edema cannot be conclusively identified as a significant cause of EIAH in moderately and highly trained athletes.
Keywords: Exercise-induced arterial hypoxemia, EIAH, desaturation in athletes, exercise limitation, interstitial pulmonary edema
EXTENSION of the file: .doc
Special (Invited) Session: Study of Exercise-Induced Hypoxemia in Athletes: Role of Interstitial Pulmonary Edema
Organizer of the Session: 650-205
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