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Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 20-613
Full Name: Lawrence Popescu
Position: Professor
Age: ON
Sex: Male
Address: Splaiul Independentei 99-101, Bucharest 050096
Country: ROMANIA
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E-mail address: lpopescu@jcmm.org
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Title of the Paper: The Tandem: Telocytes - Stem Cells
Authors as they appear in the Paper: Lawrence M. Popescu
Email addresses of all the authors: lpopescu@jcmm.org
Number of paper pages: 8
Abstract: We have recently described a novel type of interstitial (stromal) cells – Telocytes (TC) – in several cavitary and non-cavitary organs from humans and other mammalians. TC have a small cell body, but specific (unique) prolongations that we named Telopodes (Tp). Therefore, the simplest definition for TC is: cells with Tp. Tp are characterized by: a) number (1-5/cell, frequently 2 or 3); b) length (tens up to hundreds of mm); c) moniliform aspect – an alternation of thin segments, podomeres (with caliber under 200 nm, below the resolving power of light microscopy) and dilated segments, podoms, which accommodate mitochondria, (rough) endoplasmic-reticulum and caveolae, the so-called "Ca2+ uptake/ release units"; d) dichotomous branching pattern forming a 3D network, a labyrinthine system with complex homo- and heterocellular junctions, revealed only by electron tomography. Significantly, TC (especially Tp) release shed vesicles and exosomes, sending macromolecular si!
gnals to neighbor cells, thus modifying their transcriptional activity, eventually. The lenght and ramifications of Tp together with the intercellular junctions and the releasing of shed vesicles or exosomes suggest an essential role of TC in intercellular signaling and coordination. Noteworthy, at least in some organs (e.g. heart and lungs) TC and stem cells (SC) are located in tandem within the so called stem cell niches, where Tp surround stem cells (SC). TC heterocellular contacts, as well as the impulsion of shed vesicles assure TC - SC sinergy. Presumably, TC "nurse" SC in stem cell niches.
Keywords: Telocytes, Telopodes, Stem cells, Stem-cell niches, Shed vesicles / exosomes, Electron tomography
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