Papers Submitted to WSEAS Conferences and WSEAS Journals: Wseas Transactions

Friday 25 March 2011

Wseas Transactions

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The following information was submitted:

Transactions: INTERNATIONAL JOURNAL of MATHEMATICAL MODELS AND METHODS IN APPLIED SCIENCES
Transactions ID Number: 20-621
Full Name: Yongwimon Lenbury
Position: Professor
Age: ON
Sex: Female
Address: Department of Mathematics, Faculty of Science, Mahidol University, Rama 6 Rd., Bangkok 10400
Country: THAILAND
Tel: 02-201-5448
Tel prefix: 66
Fax: 02-201-5343
E-mail address: scylb@mahidol.ac.th
Other E-mails: scylb@yahoo.com
Title of the Paper: Drug Resistant and Wild-type Strains Interaction: Investigating Effects of Conversion Delays for Possible Control Strategies
Authors as they appear in the Paper: Korsuk Sirinukunwattana, Yongwimon Lenbury, Nardtida Tumrasvin
Email addresses of all the authors: the_korsuk@hotmail.com, scylb@mahidol.ac.th, scntr@mahidol.ac.th
Number of paper pages: 9
Abstract: Drug resistance arises when a drug such as an antimicrobial or an antineoplastic loses its effectiveness in curing a disease or health condition. The increasing threat of drug resistance is compromising medical care worldwide. To provide deeper understanding of possible measures to avoid the endemicity of drug resistant strains, many models have been proposed and analyzed on the dynamics of co-circulating wild-type and drug resistant viruses. We aim to add to these works by considering a model which incorporates the effects of delay in the evolution of resistant strain, as well as the role of the immune response and the target cells availability on the suppression of the peak load of resistant virus. The model is analyzed to discover possible impacts of delays on the systemâ€™s dynamic behaviour, persistence of the two strains, and the global stability. Oscillatory behaviour and the role of delays as possible control parameters are also investigated.
Keywords: Drug resistance, Cost of resistance, maturation delays effects, global stability, uniform persistence.
EXTENSION of the file: .pdf
Special (Invited) Session: Drug Resistant and Wild-type Strains Interaction: Investigating Effects of Conversion Delays for Possible Control Strategies
Organizer of the Session: 650-207
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