The following information was submitted:
Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 20-633
Full Name: Giulio Dante Guerra
Position: Doctor (Researcher)
Age: ON
Sex: Male
Address: Largo Lucio Lazzarino, I-56122 Pisa
Country: ITALY
Tel: 0502217882
Tel prefix: +39
Fax: 0502217866
E-mail address: giuliodante.guerra@diccism.unipi.it
Other E-mails: giuliodante.guerra@cnr.it
Title of the Paper: Bioresorbable microspheres as devices for the controlled release of paclitaxel
Authors as they appear in the Paper: Giulio D. Guerra, Caterina Cristallini, Niccoletta Barbani, and Mariacristina Gagliardi
Email addresses of all the authors: giuliodante.guerra@diccism.unipi.it,caterina.cristallini@diccism.unipi.it,n.barbani@diccism.unipi.it,mariacristina.gagliardi@diccism.unipi.it
Number of paper pages: 8
Abstract: The release of the anti-cancer drug paclitaxel (PTX) from microspheres of both a bioresorbable poly(ε-caprolactone-oxyethylene-ε-caprolactone) tri-block copolymer and of polyurethanes containing either copolymers with the same composition and different molecular weights or poly(ε-caprolactone) diol as soft segments was studied. The microspheres, both loaded and not with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM and DSC. The quantities of PTX released were measured by HPLC. The results showed slow and very regular releases, which fit very well the Peppas equation, Mt/M∞ = k · tn, where Mt is the amount of solute released at the time t, M∞ is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order. Most n values are consistent with non-Fickian release mechanisms, with the exceptions of two less hydrophilic polyurethanes.
Keywords: Controlled release, Microspheres, Paclitaxel, Poly(ester-ether-ester)s, Polyurethanes
EXTENSION of the file: .pdf
Special (Invited) Session: Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly(ester-ether-ester) Microspheres
Organizer of the Session: 650-243
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