The following information was submitted:
Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 20-614
Full Name: Ivayla Pantcheva
Position: Assistant Professor
Age: ON
Sex: Female
Address: 1, J. Bourchier blvd., 1164 Sofia
Country: BULGARIA
Tel: 359-2-8161446
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Fax:
E-mail address: ipancheva@chem.uni-sofia.bg
Other E-mails: ipancheva@hotmail.com
Title of the Paper: Cytotoxic and antiproliferative activities of monensic acid and its metal(II) complexes against drug sensitive and multidrug resistant human tumor cell lines
Authors as they appear in the Paper: Radostina Alexandrova , Tanya Zhivkova, Ivayla N. Pantcheva, Mariana Mitewa
Email addresses of all the authors: rialexandrova@hotmail.com, ipancheva@chem.uni-sofia.bg, ahmm@chem.uni-sofia.bg
Number of paper pages: 9
Abstract: In the present study for the first time the anticancer activity of the polyeter ionophorous antibiotic Monensic acid (MonH) and its complexes with Ca(II), Co(II) and Mn(II) ions was evaluated against the drug sensitive human squamous cell carcinoma cell line A431 and its multidrug resistant clones that express MDR1, MRP1 or ABCG2 gene. For comparative purposes the non-tumor human cell line Lep3 was also included in the experiments. The investigations were carried out using MTT test and colony-forming method. The results obtained reveal that applied at concentrations of 0.5-25 µg/mL for 24-72 h the compounds investigated decrease the viability and proliferation of the treated cells in a time- and concentration-dependent manner. The investigated metal(II) complexes (especially those of Mn(II) and Co(II)) has been found to express higher cytotoxic and cytostatic activities as compared to the non-coordinated MonH.
Keywords: Drug sensitive human squamous cell carcinoma A431, Non-tumor human cell line Lep3, Monensin biometal(II) complexes, Multidrug resistant A431 clones
EXTENSION of the file: .pdf
Special (Invited) Session: Antitumor activity of the polyether ionophorous antibiotic Monensin and its metal(II) complexes
Organizer of the Session: 650-737
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