The following information was submitted:
Transactions: INTERNATIONAL JOURNAL of BIOLOGY and BIOMEDICAL ENGINEERING
Transactions ID Number: 20-558
Full Name: Hassane Oudadesse
Position: Professor
Age: ON
Sex: Male
Address: 263, av du Général Leclerc, Campus de beualieu, Rennes
Country: FRANCE
Tel: +33 2 23 23 66 59
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E-mail address: hassane.oudadesse@univ-rennes1.fr
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Title of the Paper: 1- Chitosan Effects on Bioactive Glass for Application as Biocopmosite Biomaterial
Authors as they appear in the Paper: Hassane Oudadesse, Xuan- Vuong. Bui, Yann. Le Gal, Amani Mostafa and Guy Cathelineau
Email addresses of all the authors: hassane.oudadesse@univ-rennes1.fr, x.vbui@univ-rennes1.fr, ylegal@univ-rennes1.fr, amani.mostafa@uni-rennes1;fr, guy.cathelineau@uni-rennes1.fr
Number of paper pages: 9
Abstract: Abstract— The objective of this work was to synthesize biocomposite composed by bioactive glass (BG) and chitosan (CH) as biomaterials for medical applications. 17 wt% of chitosan polymer was added to the glass matrix by using an original method to obtain BG/CH biocomposite. The obtained biocomposite was investigated by using numerous physico-chemical methods. The homogenous distribution of bioactive glass particles within the matrix of chitosan polymer was clearly showed in this study. "In vitro" assays without cells were employed to evaluate the effect of chitosan polymer addition on the glass matrix by studying the chemical reactivity and bioactivity of the BG and BG/CH composite after different times of soaking in SBF solution. Ionic exchanges and kinetic of bioactivity were highlighted. Also, "in vitro" assays with presence of celle were studied for the cytotoxicity evaluation. The obtained results showed the formation of a biological active hydroxyapatite (H!
A) layer and highlighted the bioactivity of bioactive glass, particularly after addition of chitosan polymer. The composite based on bioactive glass and chitosan polymer has excellence ability to form an apatite layer on its surface. SEM analyses showed a dense layer of HA on the surface of BG/CH biocomposite. ICP-OES highlighted the effect of chitosan on the dissolution of the glassy network after different times of soaking. The results indicated that the presence of chitosan polymer delayed the silicon release from glassy network toward the synthetic physiological solution. The chitosan acts as capping agent.The non toxic character of this biocomposite was confirmed.
Keywords: Bioactive glass, chitosan, freeze-drying, hydroxyapatite, ''in vitro'', osteoblast.
EXTENSION of the file: .doc
Special (Invited) Session: Microspheres of Chitosan-Bioactive Glass for Application in Orthopedic Surgery. In vitro experiment
Organizer of the Session: 650 - 459
How Did you learn about congress: Nelson Camargo:camargo_n@terra.com.br, Abdallah Zrineh: azrineh@yahoo.fr
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